Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach

Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach

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Background.Transbronchial lung cryobiopsies (TBLCs) are a promising diagnostic tool in the setting of diffuse parenchymal lung diseases (DPLDs).However, no comparison with surgical lung biopsy (SLB) in the same patient is Bar:Small Kitchen Appliances:Vacuum Sealers available.Methods.

The diagnostic yield and safety data of TBLCs, as well as the result of SLB performed after TBLCs, were analysed in a multicentric Belgian study.A SLB was performed after TBLCs in absence of a definite pathological diagnosis or if a NSIP pattern was observed without related condition identified following multidisciplinary discussion.Results.Between April 2015 and November 2016, 30 patients were included.

Frequent complications included pneumothorax (20%) and bleeding (severe 7%, moderate 33%, and mild 53%).There was no mortality.The overall diagnostic yield was 80%.A SLB was performed in six patients (three without definite histological pattern and three with an NSIP).

The surgical biopsy changed the pathological diagnosis into a UIP pattern in five patients and confirmed a NSIP pattern in one patient.Conclusion.TBLCs are useful in the diagnostic work-up of DPLDs avoiding a SLB in 80% of the patients.However, surgical biopsies, performed Cardigan as a second step after TBLCs because of an indefinite diagnosis or a NSIP pattern, provide additional information supporting the interest of a sequential approach in these patients.